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KELLY LAB MEMBERS


Daniel KellyDaniel P. Kelly, M.D.

Curriculum Vitae

Lewin Professor and Chief, Cardiovascular Division;
Director, Center for Cardiovascular Research;
Professor of Medicine, Molecular Biology & Pharmacology, and Pediatrics Department of Medicine,
Washington University School of Medicine, St. Louis, MO

Teresa Leone
Teresa Leone, B.S.
(Fontbonne University)
Lab Manager

Development and characterization of genetically engineered mouse models for the Kelly laboratory.

Kari Chambers
Kari Chambers, Ph.D. (St. Louis University)

Project: Probing the role of glucotoxicity in the pathogenesis of diabetic cardiomyopathy using genetically-modified mice.
Jenny Duncan
Jenny Duncan, M.D.
(University of Chicago)
Instructor, Department of Pediatrics


Project: Mitochondrial dysfunction in the pathogenesis of diabetic cardiomyopathy
.

Steve Ewer
Steve Ewer, M.D
. (University of Michigan)
Postdoctoral Cardiology Fellow

Project: Cardiac PGC-1alpha signaling in the failing heart.

Juliet Fong
Juliet Fong, B.A.
(Washington University)
Research Technician


Assists with characterization of mitochondrial dysfunction in mouse models of diabetic cardiomyopathy
.
Carrie Gierasch


Carrie Gierasch, B.S.
(University of Missouri-Columbia)
Senior Research Technician

Ischemia-reperfusion studies of the murine diabetic heart.

Bill Kraft
Bill Kraft, B.A. (Southern Illinois University)
Electron Microscopy Research Technician


Ling Lai
Ling Lai MD, Ph.D. (Tulane University)
Postdoctoral Research Scholar


Project: Biological roles of Peroxisome Proliferator-Activated Receptor gamma coactivator-1beta (PGC-1beta) in heart and skeletal muscle

Kirk Lin
Kirk Lin, Undergraduate, Washington University School of Medicine

Project: Genotyping and characterization of genetically engineered mouse models

 

Joel Schilling


Joel Schilling, M.D., Ph.D. (Washington University School of Medicine)

Project: Crosstalk between nuclear receptor and inflammatory signaling in the normal and diseased heart.

Michelle Trusgnich


Michelle Trusgnich, B.S. (Southern Illinois University
-Edwardsville)
Sr. Research Technician

Project: Development and characterization of genetically engineered mouse models of heart disease and diabetes.

John Yang


John Yang, M.D.
(University of Missouri-Columbia)
Instructor of Medicine

Project: Characterization of the molecular pathogenesis of diabetic cardiomyopathy; identification and characterization of novel cardiac-enriched transcriptional coactivator proteins.

Christoph Zechner
Christoph Zechner, M.D.
(University of Frieburg Medical School)
Postdoctoral Research Associate


Project: PGC-1 signaling and muscle glucose metabolism

 

 

 

Former Lab Trainees

Trainee

Years

Support

Project Title

Current Position

Predoctoral

Richard Vega

95-99

NIH, Cell Biology Training Grant

Role of nuclear receptors in brown adipocyte differentiation

Scientist, Novartis Co.

Michael Kappelman

97 (summer)

WUMS Student Research Fund

Characterization of a metabolic gene regulatory pathway involved in the cardiomyocyte hypertrophic growth response

Pediatric Resident Training, Boston Childrens Hospital

Jane Bowen

97 (summer)

AHA Summer Fellowship

Identification of cardiac-specific retinoid receptor interacting proteins

Medical Student, University of North Carolina

Clovis Pitchford

98 (summer)

HHMI Summer Fellowship Award

Molecular basis of gender-specific death of PPARα-/- mice

Residency in Pathology, Vanderbilt University

Trevor Robison

98-00 (summer)

AHA Summer Fellowship

Retinoid signaling in heart


Residency in Anesthesiology, Northwestern University

Angela Raigans

98 (summer)

AHA Summer Fellowship

Is PPARα a compensatory factor in inborn errors in FAO?

Student, St. Louis College of Pharmacy

Carolyn Magee

01-02

Division of Biology and Biomedical Sciences Training Grant, Washington Univ.

Signal transduction pathways controlling nuclear receptor coactivator/corepressor function

Research Technician, Center for Cardiovascular Research, Washington University

Adam Wende

01-06

Division of Biology and Biomedical Sciences; and CV Training Grant, Washington Univ.

Regulation of the transcriptional coactivator, PGC-1 in the hypertrophied heart

Postdoctoral Research Associate, University of Utah

Tim Peterson

02 summer

WUMS Student Research Fund

Regulation of GLUT4 gene transcription by PPARα

Graduate Assistant, MIT, Department of Biology

Lauren Kim

03-05

WUMS Student Research Fund; HHMI Fellowship Award

Mapping the interaction between PGC-1α and NRF-1

Medical Student, Washington University

Lori L. LaRiviere
03-04
MSTP Training Grant Washington Univ. The influence of dietary fat content on diabetic cardiac dysfunction Medical Scientist Training Program, Washington University

Jacqueline Siljee

05-06

Departmental Funds

Mechanism of mitochondrial lipotoxicity relevant to diabetic cardiomyopathy

Graduate student, UCSF

 

Postdoctoral

M. Eric Carter, MD

91-93

Merck-ACC Fellowship

Characterization of a complex hormone responsive transcriptional regulatory element

Clinical Practice, Boise, ID

Sharon Cresci, MD

92-96

Individual NRSA, NHLBI

Isolation and characterization of a novel cardiac-enriched nuclear receptor

Instructor of Medicine, Washington University

Fiona H. Levy, MD

93-01

K08 Award, NHLBI

Hypoxia-induced gene expression

Associate Prof., Pediatrics, UT Southwestern

Dennis Disch, MD
93-95
AHA Fellowship Development of a transgenic mouse system to study the regulation of cardiac fatty acid oxidation

Clinical Practice, St. Louis, MO
Philip M. Barger, MD
93-01
NIH, Cardiovascular Pharmacology Training Grant; AHA; AHA Scientist Development Award, K08 Award, NHLBI

Retinoid X receptor-alpha gene expression in cardiac development; MAPK signaling in the heart Assistant Professor of Medicine, Baylor University School of Medicine
Michael N. Sack, MD, PhD
94-97
HHMI Postdoctoral Research Fellowship Regulation of oxidative energy enzyme gene expression in the hypertrophied failing heart

Clinician/Scientist, Cardiovascular Branch, National Heart, Lung and Blood Institute
Martha Clabby, MD
95-01
Pediatric Scientist Development Program Award; K08 Award, NHLBI

Role of retinoids in cardiac development and growth Assistant Professor of Pediatrics, Emory University
Jon Brandt, MD
96-99
Individual NRSA, NHLBI Characterization of M-CPT I expression during cardiac hypertrophic growth and development

Clinical Practice, Pediatric Hem-Onc, Green Bay, WI
Attila Kovacs, MD
95-96
Departmental Funds; AHA Scientist Development Award

Molecular basis of diabetic cardiomyopathy Assistant Professor, Washington University
John Lehman, MD
98-05

CV Training Grant, Paul B. Beeson Career Development Awards in Aging

Control of cardiac mitochondrial biogenesis by PPARα coactivator protein 1 (PGC-1) Instructor , Center for Cardiovascular Research, Dept of Medicine, Washington Univ.

David Kurtz, DVM, PhD
98-03
NIH KO1 Award The role of estrogen in the control of cardiac and hepatic lipid metabolism Veterinarian, National Exposure Research Laboratory (NERL) of the U.S. Env. Protection Agency Research Triangle Park, NC

Suresh Narayanan, MD
98-99
CV Training Grant Characterization of altered lipid metabolism in the failing heart

Clinical Practice
Janice Huss, PhD
99-06
Individual NRSA, NHLBI; KO1 Award, NIDDK PGC-1 as a coactivator of mitochondrial fatty acid oxidation

City of Hope, Duarte, CA
Brian Finck, PhD
00-05
Individual NRSA, NHLBI; KO1 Award, NIDDK Development of a mouse model of diabetic cardiomyopathy

Research Instructor of Medicine, Washington University
Paul Schaeffer, PhD
00-06
Individual NRSA Investigation of molecular signatures of physiologic cardiac hypertrophy

Assistant Professor, University of Miami, Ohio
K. George Thampy, MD
00-01
Diabetes Research Training Grant Characterization of the role of PPARα and PGC-1 in the insulin signaling pathway

Clinical Practice
Laurie K. Russell, PhD
01-04
CV Pharmacology Training Grant Development of inducible murine expression systems for PPARα and PGC-1

Assistant Professor, St. Louis University
Carl E. Clay, PhD 02-03 Developmental Cardiology and Pulmonary Training Program PPAR/RXR signaling in the hypertrophic heart Senior Medical Writer, Complete Healthcare Communications, Inc. Glen Mills, PA
Mike Brown, MD 05-07 CV Training Grant, ACC Merck Training Fellowship Award Exploring the functional role of genetic variants influencing the PGC-1 complex Cardiology Fellow, Washington University
Eileen Burkart, PhD 03-07 CV Pharmacology Training Grant, AHA Fellowship Award The role of PPARbeta in the cardiovascular system Abbott Laboratories
Jose Madrazo, MD 05-07 CV Training Grant PGC-1-driven glucose metabolism in the ischemic heart Cardiology Fellow, Washington University
 
   
Visiting Senior Scientists

Name
 
Home Institution
  Current Primary Position
Daniel Hale, MD
92-93 sabbatical
University of Pennsylvania Substrate control of fatty acid oxidation enzyme expression Associate Professor, Univ of Texas Medical School, San Antonio

Fatima Djouadi, PhD
96-97 sabbatical
INSERM, Paris A mouse model of metabolic cardiomyopathy Scientist, INSERM, University of Paris

Denis Medeiros, PhD
98-99 sabbatical
The Ohio State University, NRSA Senior Fellowship Mitochondrial biogenesis in the hypertrophied heart Professor, Chair, Dept. of Nutrition, Kansas State University

Michael Brame
03-summer
Division of Biology & Biomedical Science Young Scientist Program


Metabolic characterization of a transgenic mouse model of insulin resistance Teacher, Roosevelt High School, St. Louis, MO

 

HISTORY

Kelly Lab Photos

 

WUMS | Center for Cardiovascular Research


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