KELLY LAB SELECTED PUBLICATIONS
Wende AR, Schaeffer PJ, Parker GJ, Zechner C, Han D-H, Chen MM, Hancock CR, Huss JM, McClain DA, Holloszy JO, Kelly DP: A role for the transcriptional coactivator PGC-1a in muscle refueling. J Biol Chem. 2007 Oct 11
Huss JM, Imahashi K, Dufour CR, Weinheimer CJ, Courtois M, Kovacs A, Giguère V, Murphy E, and Kelly DP: The nuclear receptor ERRa is required for the bioenergetic and functional adaptation to cardiac pressure overload. Cell Metab., 2007;6:25-37.
Duncan JG, Fong JL, Medeiros DM, Finck BN, and Kelly DP: Insulin-resistant heart exhibits a mitochondrial biogenic response driven by the PPARa -PGC-1a gene regulatory pathway. Circulation, 2007;115:909-917.
Yang J, Sambandam N, Han X, Gross RW, Courtois M, Kovacs A, Febbraio M, Finck BN, and Kelly DP: CD36 deficiency rescues lipotoxic cardiomyopathy. Circ. Res., 2007;100:1208-1217.
Finck BN, Gropler MC, Chen Z, Leone TC, Croce MA, Harris TE, Lawrence, Jr. JC, and Kelly DP: Lipin 1 is an inducible amplifier of the hepatic PGC-1a /PPARa regulatory pathway. Cell Metab., 2006;4:199-210.
Wende AR , Huss JM, Schaeffer PJ, Giguère V, and Kelly DP: PGC-1a coactivates PDK4 gene expression via the orphan nuclear receptor ERRa: A mechanism for transcriptional control of muscle glucose metabolism. Mol. Cell. Biol., 2005;25:10684-10694.
Finck BN, Bernal-Mizrachi C, Han DH, Coleman T, Sambandam N, LaRiviere LL, Holloszy JO, Semenkovich CF, and Kelly DP: A potential link between muscle peroxisome proliferator-activated receptor a signaling and obesity-related diabetes. Cell Metab., 2005;1:133-144.
Leone TC, Lehman JJ, Finck BN, Schaeffer PJ, Wende AR, Boudina S, Courtois M, Wozniak DF, Sambandam N, Bernal-Mizrachi C, Chen Z, O Holloszy J, Medeiros DM, Schmidt RE, Saffitz JE, Abel ED, Semenkovich CF, Kelly DP. PGC-1alpha Deficiency Causes Multi-System Energy Metabolic Derangements: Muscle Dysfunction, Abnormal Weight Control and Hepatic Steatosis. PLoS Biol. 2005 Mar 15; 3(4):e101.
Finck BN, Bernal-Mizrachi C, Han DH, Coleman T, Sambandam N, LaRiviere LL, Holloszy JO, Semenkovich CF, and Kelly DP. A potential link between muscle peroxisome proliferator-activated receptor-alpha signaling and obesity-related diabetes. Cell Metabolism 2005 1:133-144.
Huss JM, Kelly DP. Mitochondrial energy metabolism in heart failure: a question of balance. J Clin Invest. 2005 Mar;115(3):547-55.
Russell LK, Finck BN, Kelly DP. Mouse models of mitochondrial dysfunction and heart failure. J Mol Cell Cardiol. 2005 Jan; 38(1):81-91. Epub 2004 Dec 8.
Huss JM, Torra IP, Staels B, Giguere V, Kelly DP. Estrogen-related receptor alpha directs peroxisome proliferator-activated receptor alpha signaling in the transcriptional control of energy metabolism in cardiac and skeletal muscle. Mol Cell Biol. 2004 Oct; 24(20):9079-91.
Huss JM, Kelly DP. Nuclear receptor signaling and cardiac energetics. Circ Res. 2004 Sep 17;95(6):568-78.
Schaeffer PJ, Wende AR, Magee CJ, Neilson JR, Leone TC, Chen F, Kelly DP. Calcineurin and calcium/calmodulin-dependent protein kinase activate distinct metabolic gene regulatory programs in cardiac muscle. J Biol Chem. 2004 Sep 17; 279(38):39593-603. Epub 2004 Jul 19.
Kelly DP, Scarpulla RC. Transcriptional regulatory circuits controlling mitochondrial biogenesis and function. Genes Dev. 2004 Feb 15; 18(4):357-68. Review
Russell LK, Mansfield CM, Lehman JJ, Kovacs A, Courtois M, Saffitz JE, Medeiros DM, Valencik ML, McDonald JA, Kelly DP. Cardiac-specific induction of the transcriptional coactivator peroxisome proliferator-activated receptor gamma coactivator-1alpha promotes mitochondrial biogenesis and reversible cardiomyopathy in a developmental stage-dependent manner. Circ Res. 2004 Mar 5; 94(4):525-33. Epub 2004 Jan 15.
Finck BN, Lehman JJ, Barger PM, Kelly DP. Regulatory networks controlling mitochondrial energy production in the developing, hypertrophied, and diabetic heart. Cold Spring Harb Symp Quant Biol. 2002;67:371-82. Review.
Kelly DP. PPARs of the heart: three is a crowd. Circ. Res. 2003;92(5):482-484.
Finck BN, Han X, Courtois M, Aimond F, Nerbonne JM, Kovacs A, Gross RW, Kelly DP. A critical role for PPARalpha-mediated lipotoxicity in the pathogenesis of diabetic cardiomyopathy: modulation by dietary fat content. Proc. Natl. Acad. Sci. USA 2003;100(3):1226-1231.
Bernal-Mizrachi C, Weng S, Feng C, Finck BN, Knutsen RH, Leone TC, Coleman T, Mecham RP, Kelly DP, Semenkovich CF. Dexamethasone induction of hypertension and diabetes is PPARalpha dependent in LDL receptor-null mice. Nat. Med. 2003;8:1069-1075.
Huss JM, Kopp RP, Kelly DP. Peroxisome proliferator-activated receptor coactivator-1alpha (PGC-1alpha) coactivates the carddiac-enriched nuclear receptor estrogen-related receptor-alpha and -gamma. Identification of novel leucine-rich interaction motif within PGC-1alpha. J. Biol. Chem. 2002;277(43):40265-40274.
Finck BN, Lehman JJ, Leone TC, Welch MJ, Bennett MJ, Kovacs A, Han X, Gross RW, Kozak R, Lopaschuk G, and Kelly DP: The cardiac phenotype induced by PPARalpha overexpression mimics that caused by diabetes mellitus. J. Clin. Invest. 2002;109:121-130.
Barger P, Browning AC, Garner AN, and Kelly DP: p38 MAP kinase activates PPARalpha: A potential role in the cardiac metabolic stress response. J. Biol. Chem. 2001;276:44495-44501.
Lehman JJ, Barger PM, Kovacs A, Saffitz JE, Medeiros D, and Kelly DP: PPARalpha coactivator-1 (PGC-1) promotes cardiac mitochondrial biogenesis. J. Clin. Invest. 2000;106:847-856.
Barger P and Kelly DP: PPAR signaling in the control of cardiac energy metabolism. Trends in Cardiovasc. Med. 2000;10:238-245.
Barger PM, Brandt J, Leone TC, Weinheimer CJ, and Kelly DP: Deactivation of the peroxisome proliferator-activated receptor alpha during cardiac hypertrophic growth. J. Clin. Invest. 2000;105:1723-1730.
Vega R, Huss, JM, and Kelly DP: The coactivator PGC-1 cooperates with PPARalpha in transcriptional control of nuclear genes encoding mitochondrial fatty acid oxidation enzymes. Mol. Cell. Biol. 2000;20(5):1868-1876.
Sack MN, Disch D, Rockman H, and Kelly DP: A role for Sp and nuclear receptor transcription factors in a cardiac hypertrophic growth program. Proc. Natl. Acad. Sci. USA 1997;94:6438-6443.
Sack MN, Rader TA, Park S, Bastin J, McCune SA, Kelly DP: Fatty acid oxidation enzyme gene expression is downregulated in the failing heart. Circulation 1996;94:2837-2842.